Traditional use: Used for over 2,000 years by Amazonian indigenous peoples—particularly the Asháninka of Peru—as a sacred immune tonic and anti-inflammatory for arthritis, digestive disorders, infections, wound healing, and female reproductive conditions. 

Potential benefits: Oxindole alkaloids and pentacyclic triterpenes deliver well-researched immunomodulatory, anti-inflammatory, antioxidant, and DNA-repair-supporting activity; clinical trials support use in rheumatoid arthritis, osteoarthritis, and as an adjunct in oncology support. 

Warnings: Contraindicated in pregnancy, autoimmune conditions, and organ transplant recipients; may interact with anticoagulants, antihypertensives, immunosuppressants, and CYP3A4-metabolized medications; distinguish from Uncaria rhynchophylla (different herb, different actions).